Participate in the Therapeutics Actionability AI Challenge
Join our community of researchers, developers, and clinicians working to unlock therapeutic insights for rare genetic disorders.
🧭 How to Participate
You can take part in the challenge in two ways:
- 📌 Submit a question about therapeutic identification or feasibility for rare disease patients.
- 🤖 Submit an AI model that answers therapeutics-related questions and/or generates a therapeutics actionability report based on structured genetic and clinical input. Submission instructions to come.
📅 Key Dates & Deadlines
| Event | Deadline |
|---|---|
| Question Submission Opens | June 1, 2025 |
| Participant Registration Begins | June 9, 2025 |
| Question Submission Closes | October 1, 2025 |
| Phase 1 Model Submission Opens | October 15, 2025 |
| Phase 1 Model Submission Closes | October 31, 2025 |
| Phase 1 Winners Announced & Phase 2 Participants Invited | December 1, 2025 |
| Phase 2 Model Submission Opens | January 15, 2026 |
| Phase 2 Model Submission Closes | January 31, 2026 |
| Phase 2 Winners Announced | March 31, 2026 |
| Phase 2 Winners Present at SAIL 2026 | May 6-9, 2026 |
Registration
Let us know you’re in! 🚀 Email your 150-300 word idea description to aitxchallenge@gmail.com.
🏆 Prizes & Incentives
☁️ $XX in Google Cloud credits
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Contenders should follow a step-by-step Google Cloud Platform (GCP) guide to set up their working environment. The first 25 participants (or teams) who submit evidence of successfully setting up their GCP environment and a 150-300 word abstract of their idea will receive $XX in GCP credit.
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Winners of Phase 1 will additionally receive $YY GCP credits to further develop their solutions for Phase 2 of the competition.
🧠 Best question cash prizes
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Questions submitted by experts in clinical genetics and drug development will be spot-checked, tested and evaluated by members of our Expert Panel.
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The top three questions submitted by unique users will receive
$3000,$1000, and$500 awards.*
*Exact amounts to be confirmed.
💰 Top model performance cash prizes
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Winners of Phase 1 will receive $300 cash prizes, an invitation to participate in Phase 2, and GCP credits for application toward the development of their Phase 2 solution.
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Winners of Phase 2 will receive a $5000 cash prize.*
*Exact amount to be confirmed.
💡 Recognition and publication
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Question submitters will be invited to co-author a post-competition publication, with author order determined by count of high-quality questions submitted.
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Winners of Phase 2 will be invited to submit their model description as a Methods article in NEJM AI and will be invited to present at SAIL 2026 in Puerto Rico.
🔧 Getting Started
- Explore our Challenge Specifications, Tutorials, and FAQs.
Let us know you’re in! 🚀 Email your 150-300 word idea description to aitxchallenge@gmail.com.