Participate in the Therapeutics Actionability AI Challenge
Join our community of researchers, developers, and clinicians working to unlock therapeutic insights for rare genetic disorders.
🧭 How to Participate
You can take part in the challenge in two ways:
- 📌 Submit a question about therapeutic identification or feasibility for rare disease patients.
- 🤖 Submit an AI model that answers therapeutics-related questions and/or generates a therapeutics actionability report based on structured genetic and clinical input. Submission instructions to come.
📅 Key Dates & Deadlines
| Event | Deadline |
|---|---|
| Question Submission Opens | June 1, 2025 |
| Participant Registration Begins | June 9, 2025 |
| Phase 1 Model Submission Opens | November 15, 2025 |
| Question Submission Closes | January 1, 2026 |
| Phase 1 Model Submission Closes | February 11, 2026 |
| Phase 1 Winners Announced & Phase 2 Participants Invited | March 4-11, 2026 |
| Phase 1 Winners Present at SAIL 2026 | May 6-9, 2026 |
| Phase 2 Model Submission Opens | TBD |
| Phase 2 Model Submission Closes | TBD |
| Phase 2 Winners Announced | TBD |
Registration
Let us know you’re in! 🚀 We’ll be in touch about model submission and status and other updates.
🔧 Getting Started
☁️ Cloud compute credits
- Google will provide $500 in GCP credit to the first 15 registered participants (or teams) who email a screenshot of successfully setting up their GCP environment. Contenders should follow this step-by-step Google Cloud Platform (GCP) guide to set up their working environment.
- AWS may provide up to $5000 in cloud credits for students, faculty, and staff who submit a project proposal through their Cloud Credit for Research program.
️ Explore
- Challenge Specifications detail expected input and output format.
- Tutorials provide further information about therapeutic challenges, biomedical resources, and compute environments for model development.
- FAQs about questions, model requirements and constraints, and more!
🏆 Prizes & Incentives
☁️ Cloud compute credits
- Winners of Phase 1 will receive $1000-5000 GCP credits to further develop their solutions for Phase 2 of the competition.
🧠 Best question cash prizes
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Questions submitted by experts in clinical genetics and drug development will be spot-checked, tested and evaluated by members of our Expert Panel.
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We will award 20 prizes of $500* each to questions sampled from the pool of accepted questions.
*Exact amounts to be confirmed.
💰 Top model performance cash prizes
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Winners of Phase 1 will receive $700* cash prizes, an invitation to participate in Phase 2, and GCP credits for application toward the development of their Phase 2 solution.
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Winners of Phase 2 will receive a $5000* cash prize.<br>*Exact amounts to be confirmed.
💡 Recognition and publication
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Question submitters will be invited to co-author a post-competition publication, with author order determined by count of high-quality questions submitted.
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Winners of Phase 1 will be invited to submit their model/solution as an article in NEJM AI and will be invited to present at SAIL 2026 in Puerto Rico.
Let us know you’re in! 🚀 Complete the registration form linked above.