Participate in the Therapeutics Actionability AI Challenge

Join our community of researchers, developers, and clinicians working to unlock therapeutic insights for rare genetic disorders.

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How to Participate

You can take part in the challenge in two ways:

• Submit a question about therapeutic identification or feasibility for rare disease patients.
• Submit an AI model that answers therapeutics-related questions and/or generates a therapeutics actionability report based on structured genetic and clinical input. Submission instructions to come.

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Key Dates & Deadlines

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Getting Started

Cloud compute credits

• Google will provide $500 in GCP credit to the first 20 participants (or teams) who register for the challenge and email a screenshot of successfully setting up their GCP environment. Contenders should follow this step-by-step Google Cloud Platform (GCP) guide to set up their working environment.
• AWS may provide up to $5000 in cloud credits for students, faculty, and staff who submit a project proposal through their Cloud Credit for Research program.

Note: Cloud credits can be redeemed by participants with GCP/AWS billing account addresses in eligible countries. Specifically, due to export-control restrictions (see U.S. Export Administration Regulations, OFAC sanctions, and U.S. Department of Commerce restrictions), promotional or research/education cloud compute credits cannot be issued to or used by individuals or institutions with billing addresses located in embargoed or excluded regions (e.g., Mainland China, Russia, Iran, North Korea, Syria, Cuba, Crimea/Donetsk/Luhansk Ukrainian territories). See the Google Cloud Locations page and AWS Global Infrastructure page for regions where credits can be applied and product availability.

Explore

• Challenge Specifications detail expected input and output format.
• Tutorials provide further information about therapeutic challenges, biomedical resources, and compute environments for model development.
• FAQs about questions, model requirements and constraints, and more!

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Prizes & Incentives

Cloud compute credits

• In each submission tier of Phase 1, one top-performing team will receive $4000 in GCP credits, and 2-3 honorable mention teams will each receive 1000 in GCP credits, all to support continued development of their solutions for Phase 2 of the competition. Model submissions will be evaluated on a curated question benchmark as described.

Best question cash prizes

• Questions submitted by experts in clinical genetics and drug development will be spot-checked, tested and evaluated by members of our Expert Panel.

• We will award 15 prizes of $500 each to questions sampled from the pool of accepted questions.

Top model performance cash prizes

• Winners of Phase 1 will receive $700 cash prizes, an invitation to participate in Phase 2, and GCP credits for application toward the development of their Phase 2 solution.

• Winners of Phase 2 will receive a $5000 cash prize.

Recognition and publication

• Question submitters will be invited to co-author a post-competition publication, with author order determined by count of high-quality questions submitted.

• Winners of Phase 1 and Phase 2 will be invited to submit their model/solution as an article in NEJM AI.

• Winners of Phase 2 will be invited to present at SAIL 2027 in Puerto Rico.