Participate in the Therapeutics Actionability AI Challenge
Join our community of researchers, developers, and clinicians working to unlock therapeutic insights for rare genetic disorders.
How to Participate
You can take part in the challenge in two ways:
- Submit a question about therapeutic identification or feasibility for rare disease patients.
- Submit an AI model that answers therapeutics-related questions and/or generates a therapeutics actionability report based on structured genetic and clinical input. Submission instructions to come.
Key Dates & Deadlines
| Event | Deadline |
|---|---|
| Question Submission Opens | June 1, 2025 |
| Participant Registration Begins | June 9, 2025 |
| Phase 1 Model Submission Opens | November 15, 2025 |
| Question Submission Closes | October 15, 2025 |
| Phase 1 Model Submission Closes | February 11, 2026 |
| Phase 1 Winners Announced & Phase 2 Participants Invited | March 4-11, 2026 |
| Phase 1 Winners Present at SAIL 2026 | May 6-9, 2026 |
| Phase 2 Model Submission Opens | TBD |
| Phase 2 Model Submission Closes | TBD |
| Phase 2 Winners Announced | TBD |
Getting Started
Cloud compute credits
- Google will provide $500 in GCP credit to the first 15 registered participants (or teams) who email a screenshot of successfully setting up their GCP environment. Contenders should follow this step-by-step Google Cloud Platform (GCP) guide to set up their working environment.
- AWS may provide up to $5000 in cloud credits for students, faculty, and staff who submit a project proposal through their Cloud Credit for Research program.
Explore
- Challenge Specifications detail expected input and output format.
- Tutorials provide further information about therapeutic challenges, biomedical resources, and compute environments for model development.
- FAQs about questions, model requirements and constraints, and more!
Prizes & Incentives
Cloud compute credits
- Winners of Phase 1 will receive $1000-5000 GCP credits to further develop their solutions for Phase 2 of the competition.
Best question cash prizes
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Questions submitted by experts in clinical genetics and drug development will be spot-checked, tested and evaluated by members of our Expert Panel.
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We will award 20 prizes of $500* each to questions sampled from the pool of accepted questions.
*Exact amounts to be confirmed.
Top model performance cash prizes
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Winners of Phase 1 will receive $700* cash prizes, an invitation to participate in Phase 2, and GCP credits for application toward the development of their Phase 2 solution.
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Winners of Phase 2 will receive a $5000* cash prize.
*Exact amounts to be confirmed.
Recognition and publication
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Question submitters will be invited to co-author a post-competition publication, with author order determined by count of high-quality questions submitted.
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Winners of Phase 1 will be invited to submit their model/solution as an article in NEJM AI and will be invited to present at SAIL 2026 in Puerto Rico.
