Participate in the Therapeutics Actionability AI Challenge

Join our community of researchers, developers, and clinicians working to unlock therapeutic insights for rare genetic disorders.

How to Participate

You can take part in the challenge in two ways:

• Submit a question about therapeutic identification or feasibility for rare disease patients.
• Submit an AI model that answers therapeutics-related questions and/or generates a therapeutics actionability report based on structured genetic and clinical input.
  • Model submission is now live!
  • Individuals and/or teams can submit.

Key Dates & Deadlines

Getting Started

• Challenge Specifications detail expected input and output format.
• Tutorials provide further information about therapeutic challenges, biomedical resources, and compute environments for model development.
• FAQs about questions, model requirements and constraints, and more!

Prizes & Incentives

Best question cash prizes

• Questions submitted by experts in clinical genetics and drug development will be spot-checked, tested and evaluated by members of our Expert Panel.

• We will award 15 prizes of $500 each to questions sampled from the pool of accepted questions.

Top model performance cash prizes

• Winners of Phase 1 will receive $700 cash prizes.

• Winners of Phase 2 will receive a $5000 cash prize.

Recognition and publication

• Question submitters will be invited to co-author a post-competition publication, with author order determined by count of high-quality questions submitted.

• Winners of Phase 1 and Phase 2 will be invited to submit their model/solution as an article in NEJM AI.

• Winners of Phase 2 will be invited to present at SAIL 2027 in Puerto Rico.