Join a community of researchers, developers, and clinicians working to turn rare disease diagnoses into actionable treatment options. Registration is open to individuals and teams, and the final challenge is accepting submissions now.

Key Dates

  • June 1, 2025 Question benchmark curation opens
  • June 9, 2025 Participant registration begins
  • Nov 15, 2025 Question-Answering Task submissions open
  • June 30, 2026 Question-Answering Task submissions close
  • Oct 8, 2026 Model evaluation on hypothetical patients for Actionability Report Generation began
  • Jan 25, 2027 Winners announced (by this date)
  • May 11–14, 2027 Winners present at SAIL 2027

Register

Let us know you’re in. We’ll be in touch about model submission, status, and other updates. Registration is free, and registering does not commit you to submitting.

Registration

Prizes & Incentives

Cash Prizes*

  • $500 × 15 to benchmark question submitters, sampled from the pool of accepted questions.
  • $12,500 in cash prizes to the winners of the final Actionability Report Generation challenge.

Conference Presentation

  • Winners of the final challenge are invited to present at SAIL 2027 in Puerto Rico, May 11–14, 2027.

Authorship

  • Winners of the final challenge are invited to submit their solution as an article in NEJM AI.
  • Question submitters and Question-Answering Task winners are invited to co-author a post-competition publication.

* Cash prizes are taxable. Cash prizes paid by Harvard University are generally taxable to the recipient. Harvard must collect tax documentation from each winner to meet its U.S. tax reporting and withholding obligations. Before payment, each winner must provide Harvard with the tax forms and identification information Harvard requests. A U.S. citizen or U.S. tax resident will generally be required to provide IRS Form W-9. A non-U.S. tax resident will generally be required to provide the applicable IRS Form W-8 and any additional documentation needed to determine whether tax withholding or treaty benefits apply. If a winner does not provide the requested documentation, payment may be delayed, or Harvard may withhold tax at the highest applicable rate.

Harvard will deduct any tax withholding required by law from the stated prize amount. Harvard will issue any required tax reporting form, which may include IRS Form 1099-MISC or IRS Form 1042-S. Each winner is responsible for any taxes that are not withheld and should consult an independent tax adviser regarding their individual circumstances. Harvard cannot provide personal income tax advice or assist winners in preparing tax returns.

If a winner is a Harvard employee, the prize may be treated as taxable wages, subject to payroll tax withholding and reported on IRS Form W-2 rather than the forms described above.

Next Steps


Still have questions? See the FAQ for challenge scope, model requirements, and constraints.


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